Comparative antitumor activities of 7-N-(p-hydroxyphenyl)mitomycin C (M-83) and mitomycin C.
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منابع مشابه
Phage inactivation and DNA strand scission activities of 7-N-(p-hydroxyphenyl)mitomycin C.
A new derivative of mitomycin C (MMC), 7-N-(p-hydroxyphenyl)mitomycin C (M-83), had higher phage inactivation activity against phages phiX174 and PM2 than MMC, and also higher DNA strand scission activity against their single- and double-stranded DNAs. M-83, at one third to one sixth concentration of MMC, showed the same level of phage inactivation and DNA strand scission activities. The mechan...
متن کاملAntitumor activity and pharmacokinetics of 7-N-(p-hydroxyphenyl)mitomycin C in human tumor xenografts transplanted into nude mice.
The effects of 7-N-(p-hydroxyphenyl)mitomycin C (M-83), a derivative of mitomycin C, against eight human tumor xenografts serially transplanted into male BALB/c nude mice were evaluated. M-83 showed positive antitumor effect against six out of eight tumor strains. The antitumor spectrum of this agent was similar to that of mitomycin C except for two strains. The serum level of M-83 detected by ...
متن کاملDevelopment and application of a sensitive enzyme immunoassay for 7-N-(p-hydroxyphenyl)mitomycin C.
An antibody specific for 7-N-(p-hydroxyphenyl)mitomycin C (M-83) was developed and used in a simple and sensitive enzyme immunoassay for detection of this anticancer drug in serum. The imino group of M-83 was covalently coupled to mercaptosuccinyl groups introduced into bovine serum albumin with a cross-linker, N-maleoylaminobutyric acid. The resulting conjugate was then used for the production...
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It is probably very hard to develop a new model checker that is faster than UPPAAL for verifying (correct) timed automata. In fact, our tool MCTA does not even try to compete with UPPAAL in this (i. e., UPPAAL’s) arena. Instead, MCTA is geared towards analyzing incorrect specifications of timed automata. It returns (shorter) error traces faster.
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A framework for modelling memory consistency is presented. The framework is used to specify the operation of a total-store-order write buffer multiprocessor machine. The framework is used again to specify a more abstract “programmer-centric” model that does not refer to the write-buffer architecture. Finally, we prove that the abstract model correctly captures the computations of the operationa...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1983
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.36.559